Shahrekord University of Medical Sciences Future Natural Products 2783-4662 4 3 2018 07 31 Antimicrobial activity of methanol extract of Citrullus colocynthis against antibiotic-resistant Staphylococcus aureus 64 72 EN Khadije Rezaie Keikhaie Saeedeh Ghorbani Zahra Hosseinzadeh Mehdi Hassanshahian Journal Article 2017 04 17 2017 06 21 Background and aims: Staphylococcus aureus and anaerobic gram-positive cocci, are medically the most important species in the genus Staphylococcus. Sometimes, the bacteria are called S. aureus. The constantly growing antibiotic-resistant bacterium is very important in treatments. The aim of this study is to evaluate the antimicrobial activity of ethanol extract from Citrullus colocynthis against the S. aureus resistant to antibiotics. Methods: S. aureus strains were isolated from the city of Zabol and C.colocynthis extract was prepared using rotary devices and the MIC and MBC were determined by the microdilution method. Results: The results of this study showed that the extract from C. colocynthis inhibits the growth of bacteria in different concentrations, and that despite the relative strength of most species with different concentrations, the highest sensitivity was observed in concentrations of 10 and 20 mg/ml, in which is 100% bacteria were gone. C. colocynthis extract at a concentration of approximately 5 mg /ml had the highest inhibitory effect. Conclusion: The results showed high antimicrobial effects of ethanol extract of C. colocynthis, which can offer appropriate drug therapy