Shahrekord University of Medical Sciences Future Natural Products 2783-4662 10 1 2024 12 31 Hematological Changes Provoked by Natural Alkaloids 44 51 10.34172/fnp.167 EN Olubayode Bamidele https://orcid.org/0000-0002-8591-034X Abigail Oluwatomisin Popoola https://orcid.org/0009-0004-0911-6250 Lawrence Dayo Adedayo https://orcid.org/0000-0002-2686-9009 Funmilola Adelowo https://orcid.org/0009-0006-4535-1340 David Inaolaji https://orcid.org/0009-0002-1383-1498 Dennis Seyi Arokoyo https://orcid.org/0000-0001-8975-5300 REVIEW 10.34172/fnp.167 2024 03 06 2024 10 22 Background and aims: Plant alkaloids are naturally occurring nitrogen-containing chemicals with a wide range of therapeutic applications. They have been reported to cure a considerable number of illnesses, including cancer, diabetes, malaria, and heart dysfunction. This study sought to evaluate the impact of several plant alkaloids on hematological parameters in animals. Methods: The results of different plant extracts containing alkaloids in laboratory animals on hematological indices such as red blood cell (RBC) count, hemoglobin (Hb) concentration, hematocrit (Hct), white blood cell count, platelet count, and others using normal laboratory methods were gathered from scientific papers and databases using keywords such as plant alkaloids, alkaloid toxicity, hematological parameters, hematological changes, blood, and animals. Results: Plant alkaloids identified through the search had different impacts on hematological indices. Some alkaloids raised RBC count, Hb concentration, and Hct, while others lowered these values. Platelet count was generally observed to increase, but there were exceptions. Certain alkaloids found in some plants have no substantial influence on hematological parameters. Conclusion: Plant alkaloids can cause various changes in hematological parameters in animals. These alterations might be useful or deleterious depending on the alkaloid and its concentration. Understanding these effects is essential for the safe and effective use of plant-based therapies.