Shahrekord University of Medical Sciences Future Natural Products 2783-4662 11 1 2026 10 20 Potential Pharmacological Activities of Medicinal Plants and Their Phytochemicals Against Dengue Virus Serotypes: A Review 27 36 10.34172/fnp.335 EN Majedul Hoque https://orcid.org/0009-0001-9044-411X REVIEW 10.34172/fnp.335 2025 10 19 2025 12 06 Introduction: The dengue virus (DENV), with four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), continues to pose a threat to global public health, with no effective antiviral treatment. This review aimed to analyze the published evidence, including in vitro, in vivo, and in silico research, about medicinal plants and plant-derived compounds tested against the different serotypes of the DENV. Methods: Scientific databases, including NIH, PubMed, ScienceDirect, Google Scholar, Scopus, and EBSCO, were thoroughly searched for relevant publications through June 2025. Different keywords, such as dengue virus, DENV serotypes, antiviral activity of plants, anti-dengue activity of medicinal plants, potential anti-dengue phytochemicals, and plant compounds having anti-dengue activity, were included in the search strategy to find the most relevant studies, reviews, and literature. Results: Compound of medicinal plants (e.g., andrographolide), flavonoid compounds (e.g., quercetin and kaempferol), methyl gallate and anacardic acid, and several triterpenoids were predicted by docking and phytochemical analyses, indicating that they bind to the NS2B-NS3 protease enzyme of the DENV and are important leads with multi-serotype or strong serotype-specific inhibition. In general, most high-quality experimental data are available only from in vitro tests, which often use DENV-2, and there are few comprehensive in vivo or clinical assessments. Conclusion: Anti-dengue drugs can be derived from a variety of plant compounds and phytochemicals.