Shahrekord University of Medical Sciences Future Natural Products 2783-4662 9 1 2023 08 05 Nephroprotective effect of Anacardium occidentale (cashew) apple juice on kidney of paracetamol-induced injury in Albino rats 31 37 10.34172/fnp.2023.05 EN Joseph Oyepata Simeon https://orcid.org/0000-0001-9490-3574 Sabastine Aliyu Zubairu https://orcid.org/0000-0003-0990-9838 Joseph Opeyemi Tosin https://orcid.org/0000-0003-4272-4501 Journal Article 10.34172/fnp.2023.05 2022 12 25 2023 05 23 Background and aims: Cashew is an evergreen tropical tree native to South America. It has spread to several locations around the globe, including Africa. The plant’s various parts have been effective in treating a variety of diseases. This study aims to assess the nephroprotective effect of aqueous Anacardium occidentale cashew apple juice on the kidney of paracetamol (PCM)-induced injury in albino rats. Methods: Wistar rats were used to conduct this study. Group 1 was given saline as usual. While groups 3, 4, and 5 were administered 1, 2, and 4 ml/kg of the aqueous extract, group 2 received normal saline. In groups 2-5, animals received oral PCM 2000 mg/kg body weight on the eighth day. All animals were weighed again and sacrificed under a light diethyl ether vapor 20 hours after the last dose administration. Results: The extract significantly (P<0.05) raised packed cell volume (PCV), white blood cell (WBC), red blood cell (RBC), hemoglobin (Hb), and platelet values compared to group 2. There was no significant difference (P>0.05) in the weight-to-body size ratio of rats in none of the groups given extracts (P<0.05) when compared to group 2. Creatinine and urea level were considerably lower in the groups who received extract. Additionally, histological research supports biochemical parameters. Conclusion: The study shows that A. occidentale cashew apple may help manage renal disorders and protect the kidney against hazardous substances.